Titlebook: Resistance of Cancer Cells to CTL-Mediated Immunotherapy; Benjamin Bonavida,Salem Chouaib Book 2015 Springer International Publishing Swit

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Overcoming Cancer Cell Resistance to Death Receptor Targeted Therapiesracterized by an intracellular death domain, which transmits a death signal from their cognate ligands, including TNF-related apoptosis inducing ligand (TRAIL). Currently, multiple clinical trials are underway to evaluate the antitumor activity of recombinant human TRAIL and agonistic antibodies to

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Epithelial Mesenchymal Transition Influence on CTL Activity to promote invasion and metastasis. This review critically assesses whether EMT confers stemness, resistance to chemo- and targeted therapeutics, and immune escape. EMT inducers share common targets that alter apico-basal polarity, intercellular adhesion and the actin cytoskeleton, events that also