| 书目名称 | Resistance of Cancer Cells to CTL-Mediated Immunotherapy | | 编辑 | Benjamin Bonavida,Salem Chouaib | | 视频video | | | 概述 | Explores the inhibition of CTL-cytotoxic function by tumor-derived T-regulatory cells, along with the inhibition of cytotoxic function by tumor induction of hypoxia.Discusses the overexpression of tra | | 丛书名称 | Resistance to Targeted Anti-Cancer Therapeutics | | 图书封面 |  | | 描述 | This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more. | | 出版日期 | Book 2015 | | 关键词 | HDAC inhibitors; Proteasome inhibitors; apoptosis; cytotoxic t lymphocytes; drug-resistant cancer cells; | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-17807-3 | | isbn_softcover | 978-3-319-38067-4 | | isbn_ebook | 978-3-319-17807-3Series ISSN 2196-5501 Series E-ISSN 2196-551X | | issn_series | 2196-5501 | | copyright | Springer International Publishing Switzerland 2015 |
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发表于 2025-3-21 16:37:49
