Titlebook: Research in Computational Molecular Biology; 13th Annual Internat Serafim Batzoglou Conference proceedings 2009 Springer-Verlag Berlin Heid

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How Many Bootstrap Replicates Are Necessary?,computed at runtime to determine when enough replicates have been generated, and report on the first large-scale experimental study to assess the effect of the number of replicates on the quality of support values, including the performance of our proposed criteria. We run our tests on 17 diverse re

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Combinatorial Algorithms for Structural Variation Detection in High Throughput Sequenced Genomes,y, the few existing algorithms for identifying structural variation among individuals using paired-end reads have not been designed to handle the short read lengths and the errors implied by these platforms. Here, we describe, for the first time, algorithms for identifying various forms of structura

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