Titlebook: Research in Computational Molecular Biology; 24th Annual Internat Russell Schwartz Conference proceedings 2020 Springer Nature Switzerland

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Matthew A. Reyna,Uthsav Chitra,Rebecca Elyanow,Benjamin J. Raphaelbiological membranes are, at this time, mostly speculative and require more research to fully define the processes involved in polynucleotide transport. This chapter will discuss what is known about the uptake of naked foreign DNA by muscle cells after intramuscular injection or implantation as well

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Hongyu Zheng,Carl Kingsford,Guillaume Marçaisoth . and . systems for gene delivery and the identification of novel classes of therapeutic genes. The recent results obtained by gene therapy of inherited blindness and of some neurodegenerative disorders, as well as the progress made in several other clinical trials, now encourage informed and fi

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cles on epigenic elements, viral vectors, non-viral vectors as gene delivery systems, animal models of human diseases, inducible regulatory systems, gene therapy of cancer, AIDS, monogenic disorders and ongoing clinical trials. Gene therapy is the logical progression to human health management becau

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Jasmijn A. Baaijens,Leen Stougie,Alexander Schönhuthinant genes into living cells and to permanently transduce them with a new genetic phenotype. During the last 15 years substantial progress has been made to produce safe and effective viral vectors, and we have witnessed an exponential growth in preclinical research and clinical development of recom

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Anton Bankevich,Pavel Pevznerould be considered a form of gene therapy. The con­ cept of transfer of genetic information as a practical clinical tool arose from the gene-cloning technology, developed during the 1970s. Without the ability to isolate and replicate defined genetic sequences, it would be impossible to produce purified materi978-3-0348-7013-9978-3-0348-7011-5

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Nico Borgsmüller,Jose Bonet,Francesco Marass,Abel Gonzalez-Perez,Nuria Lopez-Bigas,Niko Beerenwinkelansfer into the stem cell of the hematopoietic system, thus allowing the appropriate expression of the normal gene into the affected cells of hematopoietic or lymphoid lineage [33–35]. However, initial difficulties in obtaining efficient transduction of stem cells have led several investigators to a

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Kristen Emery,Syamand Hasam,William Stafford Noble,Uri Keichrection of human diseases. The latter aspects emphasized themes related to biotechnology, the first part was by nature more general. We also included a few cont978-3-642-64704-8978-3-642-61122-3Series ISSN 1010-8793

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Leonard Bohnenkämper,Marília D. V. Braga,Daniel Doerr,Jens Stoyeex gene synthesis process, while refining their understanding of gene synthesis and determine what part of the process they can or should do in their laboratory and what parts should be contracted to a speciali978-1-4939-6200-6978-1-61779-564-0Series ISSN 1064-3745 Series E-ISSN 1940-6029

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