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Titlebook: Research in Computational Molecular Biology; 20th Annual Conferen Mona Singh Conference proceedings 2016 Springer International Publishing

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Simona Cristea,Jack Kuipers,Niko Beerenwinkeld mutagenesis in ES cells, allowing efficient and precise gene disruption. In combination with the use of site-specific DNA recombinases, in particular the Cre/loxP system, gene disruptioncan be directed to spe978-1-62703-834-8978-1-59745-471-1Series ISSN 1064-3745 Series E-ISSN 1940-6029
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A MAD-Bayes Algorithm for State-Space Inference and Clustering with Application to Querying Large Cotypes rely on individual analysis of each dataset (i.e., peak calling) independently. This approach discards the fact that functional elements are frequently shared among related cell types and leads to overestimation of the extent of divergence between different ChIP-seq samples. Methods geared tow
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pathTiMEx: Joint Inference of Mutually Exclusive Cancer Pathways and Their Dependencies in Tumor Proe way to a more profound understanding of tumorigenesis. In this regard, two fundamental questions have emerged: (1) which alterations drive tumor progression? and (2) what are the evolutionary constraints on the order in which these alterations occur? Answering these questions is crucial for therap
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