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Titlebook: Research in Computational Molecular Biology; 20th Annual Conferen Mona Singh Conference proceedings 2016 Springer International Publishing

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A MAD-Bayes Algorithm for State-Space Inference and Clustering with Application to Querying Large Cos the underlying state-space (e.g., bound vs. unbound) and also groups loci with similar patterns together, its Expectation-Maximization based estimation structure hinders its applicability with large numbers of loci and samples. We address this limitation by developing a MAP-based Asymptotic Deriva
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pathTiMEx: Joint Inference of Mutually Exclusive Cancer Pathways and Their Dependencies in Tumor Protion procedure to jointly optimize the assignment of genes to pathways and the evolutionary order constraints among pathways. On cancer data, pathTiMEx recapitulates previous knowledge on tumorigenesis, such as the temporal order among pathways which include ., . and . in colorectal cancer, while al
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New Genome Similarity Measures Based on Conserved Gene Adjacenciesalysis. Such methods are called ...In this paper, we study an intermediate approach between family-based and family-free genomic similarity measures. The model, called ., is on the one hand more flexible than the family-based model, on the other hand the resulting data structure is less complex than
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