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Titlebook: Renal Tumors of Childhood; Biology and Therapy Kathy Pritchard-Jones,Jeffrey S. Dome Book 2014 The Editor(s) (if applicable) and The Author

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发表于 2025-3-21 16:59:09 | 显示全部楼层 |阅读模式
书目名称Renal Tumors of Childhood
副标题Biology and Therapy
编辑Kathy Pritchard-Jones,Jeffrey S. Dome
视频video
概述Integrates state of the art information on biological advances and clinical dilemmas in a format that will be easily understandable for practising clinicians and research scientists.Documents the rece
丛书名称Pediatric Oncology
图书封面Titlebook: Renal Tumors of Childhood; Biology and Therapy Kathy Pritchard-Jones,Jeffrey S. Dome Book 2014 The Editor(s) (if applicable) and The Author
描述This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. All of the authors are experts from Europe and North America and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.
出版日期Book 2014
关键词Childhood Cancer; Kidney; Nephroblastomatosis; Wilms Tumours; surgical oncology
版次1
doihttps://doi.org/10.1007/978-3-662-44003-2
isbn_softcover978-3-662-51918-9
isbn_ebook978-3-662-44003-2Series ISSN 1613-5318 Series E-ISSN 2191-0812
issn_series 1613-5318
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
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发表于 2025-3-21 22:53:29 | 显示全部楼层
Genetic Predisposition to Wilms Tumour,mours occur in approximately 5 % of cases, and Wilms tumour has been reported in association with more than 50 different genetic disorders, pointing to an underlying predisposition in further individuals. There is conclusive evidence of an increased risk of Wilms tumour in only a small number of dis
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Clinical Presentation,en. However, specific details of the history, physical exam and laboratory evaluation can raise the suspicion of WT even prior to imaging or surgical procedures. Other renal tumors, such as rhabdoid tumor of the kidney (RTK), congenital mesoblastic nephroma (CMN), clear cell sarcoma of the kidney (C
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Treatment of Wilms Tumour: The SIOP Approach,pre-, intra- and postoperatively as well as chemotherapy were used, and pretreatment prior to surgery was widely accepted. However, the optimum timing of nephrectomy was the subject of lively debate between institutions. The improving imaging modalities and thus reliable radiologic diagnosis of neph
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Molecular-Targeted Therapy for Pediatric Renal Tumors,loped countries, and as such, treatment of Wilms’ tumor is regarded as one of the great successes in pediatric oncology. Without diminishing the import of such progress, it should be noted, however, that universal cure is not a reality and cure rates remain poor in developing countries where the del
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