Titlebook: Regulatory Protein Modification; Techniques and Proto Hugh C. Hemmings (MD,PhD) Book 1997 Humana Press 1997 Nervous System.brain.neurons.ne

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Protein Kinase and Phosphatase Inhibitors, the state of phosphorylation of specific proteins in target cells (Walaas and Greengard, 1991). Inhibitors of protein kinases and protein phosphatases are useful tools in evaluating the physiological roles of protein phosphorylation signaling mechanisms, and may ultimately find therapeutic applicat

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Identification of Posttranslational Modification Sites by Site-Directed Mutagenesis, (Wold and Moldave, 1984; Freedman and Hawkins, 1985; Harding and Crabbe, 1992). These posttranslational modifications are essential to the vitality of all eukaryotic cells, including neurons. Techniques that identify amino acid residues in a given protein that are modified and assess the effect of

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Long-Chain Fatty Acylation of Proteins,difications has been a principal route of access to signaling mechanisms. Ten years ago, for example, tyrosine phosphorylation was an intriguing oddity—a posttranslational modification known to occur in virtually all eukaryotic cells and to be regulated by various manipulations that alter cell growt

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