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Titlebook: Regulatory Peptides; Julia M. Polak Book 1989 Birkhäuser Verlag 1989 Europe.growth.research.science.system.time.visualization

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Peptides in the mammalian cardiovascular systemcance has still to be established. They may act directly via specific receptors and/or indirectly by influencing the release and action of other cardiovascular transmitters. In marked contrast, atrial natriuretic peptide is produced by cardiac myocytes and considered to act as a circulating hormone.
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Aspects of measurement and analysis of regulatory peptidesdioimmunoassay technique is becoming outdated. Pure monoclonal antibodies allow excess antibody two-site assay techniques with a variety of different labels (preferentially non-radioactive) of great sensitivity and speed. The large amounts of particular monoclonal antibodies available allow several
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The use of cell and tissue culture techniques in the study of regulatory peptidesiffusion delays and barriers to applied substances are minimised, the humoral and cellular components of the culture environment can be controlled and progressive changes in intracellular and intercellular events can be directly monitored. These significant advantages mean that culture preparations
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Quantitative analysis of autoradiogramsde receptors in the brain and peripheral tissues and more recently has been used to measure mRNA in tissue sections by . hybridisation. The spatial distribution of radiolabelled substances in tissue can be detected by the blackening of the emulsion in sheets of radiation-sensitive film and the resul
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Coexistence of peptides with classical neurotransmitters, 5-hydroxytryptamine, catecholamines, γ-aminobutyric acid (GABA) etc. This raises the possibility that neurons produce, store and release more than one messenger molecule. The exact functional role of such coexisting peptides is often difficult to evaluate, especially in the central nervous system.
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