Titlebook: Regulation of the Contractile Cycle in Smooth Muscle; Takeshi Nakano (Professor),David J. Hartshorne (Pr Conference proceedings 1995 Sprin

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Cytosolic Calcium Concentration-Force Relation in Vascular Smooth Muscle,e relation during contraction and relaxation. During both high external K.- and stable thromboxane A. analog (U-46619)-induced contractions the actively developed force was much greater at a high resting load, although the [Ca.]. transients were not affected by changes in the resting load. The basic

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Regulation of Ca2+-Dependent Phosphorylation of 20-kDa Myosin Light Chain by the Small Molecular Weion of 20-kDa myosin light chain (MLC.) in skinned smooth muscle preparations. In β-escin-permeabilized cultured aortic smooth muscle cells, GTPγS enhances Ca.-induced phosphorylation of MLC. in a concentration-dependent manner, which is inhibited by the nonhydrolyzable GDP analog guanosine 5′-O-(β-

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Regulation of Myosin Light Chain Kinase Activity in Smooth Muscle,tractility. The quantitative relation between intracellular Ca. concentrations and light chain phosphorylation is not fixed but modulated dynamically by various regulatory processes. Most of the calmodulin in smooth muscle cells is tightly bound to cellular elements even in the absence of Ca.. Surpr

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Actin-Binding Property of Myosin Light Chain Kinase and Its Role in Regulating Actin-Myosin Interacto the kinase activity innate in MLCK. We have found that this property exerts an inhibitory effect on the ATP-dependent interaction between actin and myosin. The N-terminal, actin-binding fragment was responsible for the inhibition. Calmodulin in the presence of Ca. (Ca./CaM) efficiently relieved t

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Pharmacomechanical Coupling Through Regulation of Myosin Light Chain Phosphatase,ibed. Desensitization of phasic smooth muscles to Ca. is demonstrated through time-dependent divergence, during relaxation, between the level of Ca. and the decline in MLC. phosphorylation and force. Possible mechanisms of desensitization include down-regulation of myosin light chain kinase and up-r