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Titlebook: Regulation of Ovarian and Testicular Function; Virendra B. Mahesh,Dharam S. Dhindsa,Satya P. Kalr Book 1987 The Editor(s) (if applicable)

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Book 1987ystems that comprise the reproductive system and encompass molecular events and structure-function relationships. It becomes important to review these advances in knowledge, at periodic intervals, with respect to feedback systems and regulatory loops that control reproductive processes in vivo. Towa
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Receptor-Weighted Mechanistic Approach to Analysis of the Actions of Estrogen and Progesterone on Go reproductive physiology; to the extent that we are lacking in a thorough basic understanding of these phenomena, the superstructure of endocrine-based manipulation of reproductive function collapses. Realization of this fact accounts for the vast number of experimental approaches which have been ta
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The Steroid-Neuropeptide Connection in the Control of LHRH Secretionp of the hypothaiamo-pituitary-gonadal axis is well established. In 1932, Moore and Price proposed that a tight reciprocal relationship between the gonad and the pituitary was responsible for maintaining gonadal function in the adult rat (Fig. 1). Intensive investigations over the intervening years
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Transmembrane Signals and Intracellular Messengers Mediating LHRH and LH Secretionponent in this system is the hypothalamic peptide luteinizing hormone-releasing hormone (LHRH), a decapeptide produced by neurons located in the hypothalamic-preoptic region. After synthesis, LHRH is transported to nerve terminals located in the median eminence, where it is released in close proximi
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Regulation of Pulsatile Luteinizing Hormone Release During the Estrous Cycle and Pregnancy in the Ra al., 1985) occurs in a pulsatile manner. Moreover, changes in the amplitude and frequency characteristics of this secretion take place with different stages of the 4-day estrous cycle and during different stages of gestation in this species. Plasma levels of estradiol (E.) and progesterone (P) also
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Role of Prolactin in the Regulation of Sensitivity of the Hypothalamic-Pituitary System to Steroid Ferful inhibitory control by gonadal steroids and their metabolites. Implicit in the existence of this mechanism for maintaining homeostasis is the requirement for some means of control of the sensitivity to negative steroid feedback. During sexual maturation, increased secretion of gonadotropins sti
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