Titlebook: Regulation of Gene Expression and Brain Function; Paul J. Harrison Conference proceedings 1994 Springer-Verlag Berlin Heidelberg 1994 Alzh

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Sorting and Intracellular Transport of RNA in Neurons: Regulation of Gene Expression at Synaptic Sior what Cajal called the “dynamic polarization of the neuron.” Axons are specialized for transmitting information over great distances, dendrites and cell bodies for receiving and integrating inputs from other cells, and synapses for communicating information from one neuron to the next. Each of the

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,Expression of the ,-Amyloid Precursor Protein Gene and the Pathogenesis of Alzheimer’s Disease,With the increasing number and proportion of elderly people, AD has become one of the major diseases in terms of prevalence, morbidity, mortality, and financial implications. As a consequence, investigation into its pathogenesis has become a health priority, since it is only in this way that effecti

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0941-9772 ophrenia. Generouslyillustrated, thecontributions provide a valuable outline ofthis key aspect of molecularneurobiology and clinicalneuroscience.978-3-540-57156-8978-3-642-78458-3Series ISSN 0941-9772

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Introduction: Gene Expression in the Brain,ting the genes that encode these proteins. However, there is a considerable potential gulf in understanding between a gene and its protein product. This volume of . attempts to bridge this gap by highlighting gene expression, the pathway along which the genetic information contained in DNA is realized through the synthesis of proteins.

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,Chromatin Structure, Gene Expression, and Nuclear Aluminum in Alzheimer’s Disease,initial “loosening up” of local chromatin structure within the nucleus to create a chromatin configuration that enables specific DNA sequences to be recognized by basal transcription factors and RNA polymerase systems.

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