Titlebook: Regulation of Alternative Splicing; Philippe Jeanteur Book 2003 Springer-Verlag Berlin Heidelberg 2003 Drosophila.Nucleotide.RNA.RNA Splic

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Alternative Pre-mRNA Splicing and Regulation of Programmed Cell Death,athogenesis of a large number of human diseases. PCD is under complex regulation at multiple levels. An important level of this regulation is at the level of pre-mRNA splicing because a number of PCD regulatory genes are expressed as functionally distinct or even antagonistic isoforms as a result of

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Foment

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Prediction and Statistical Analysis of Alternatively Spliced Exons,enerate them. Sequence analysis shows that alternative exons often have unusual lengths, suboptimal splice sites and characteristic nucleotide patterns. Despite this progress alternative exons cannot be predicted . from genomic data, which is due to the degenerate nature of splicing signals.

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Book 2003from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrence

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Alternative Pre-mRNA Splicing and Neuronal Function,ms has started to identify the molecular components that determine these splicing switches. This review describes how alternative splicing is central to the control of neuronal function, and what is currently known about its mechanisms of regulation. How errors in splicing might contribute to diseases of the nervous system is also discussed.

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