Titlebook: Recombinant Virus Vaccines; Methods and Protocol Maureen C. Ferran,Gary R. Skuse Book 2017 Springer Science+Business Media LLC 2017 Parvovi

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phase-2-enzyme

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Alphavirus-Based Vaccinesne development. Immunization in preclinical animal models has been conducted with naked RNA replicons, recombinant viral particles and layered DNA–RNA vectors. Most commonly, the targets for the immunization have been viral surface proteins and tumor antigens, which have elicited strong immune respo

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muster

Bacteriophage T4 as a Nanoparticle Platform to Display and Deliver Pathogen Antigens: Construction obility and low immunogenicity of such vaccines demand an efficient delivery system to stimulate robust immune responses. The bacteriophage T4 capsid-based antigen delivery system can robustly elicit both humoral and cellular immune responses without any adjuvant. Therefore, it offers a strong promis

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Fowl Adenovirus-Based Vaccine Platform-9 or wild type FAdmid) containing the entire viral genome in a cosmid vector. The viral DNA is subsequently released from the cosmid by restriction enzyme digestion followed by transfection in a chicken hepatoma cell line (CH-SAH). Virus is harvested, propagated, and verified for foreign gene expression.

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Human Rhinovirus-A1 as an Expression Vectory stable recombinant HRV (rHRV) without affecting viral replication capability. We have previously used these methods to generate live, genetically stable recombinant HRVs encoding HIV Gag and Tat proteins (rHRV-Gag-Tat), a potential mucosally targeted HIV vaccine.

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Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platformdvantages over mammalian virus vectors due to their genetic tractability, inexpensive production, suitability for scale-up, as well as their physical stability, making them an attractive vaccine platform.