Titlebook: Recombinant Virus Vaccines; Methods and Protocol Maureen C. Ferran,Gary R. Skuse Book 2017 Springer Science+Business Media LLC 2017 Parvovi

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Generating Recombinant Vesicular Stomatitis Viruses for Use as Vaccine Platformse recombinant VSV viruses that express glycoproteins of other viruses, researchers now have the means to generate vaccine candidates targeting a variety of human pathogens. This chapter gives a general overview of the workings of VSV as a vaccine platform and provides a detailed protocol for the generation of recombinant VSV from plasmids.

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Development of Novel Vaccines Against Infectious Diseases Based on Chimpanzee Adenoviral Vectors in vaccine research and development. It can induce not only potent humoral but also cellular immune responses, and has therefore been widely applied in basic and translational studies. Chimpanzee Ad is a rare serotype circulating in humans. This circumvents the problem of preexisting immunity to h

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Development of Recombinant Canarypox Viruses Expressing Immunogensonses and their incompetence to replicate in mammalian cells (safety profile). In addition, CNPV and the derived recombinants can be manipulated under biosafety level 1 conditions. There is no commercially available system to obtain recombinant CNPV; however, the methodology and tools required to de

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Development of Recombinant HSV-Based Vaccine Vectorsstromal keratitis, and encephalitis. Attempts to generate efficacious vaccines to date have failed. We have recently described the use of a conditionally replication-competent HSV-1 vector to immunize mice against a lethal challenge of HSV-1. The unique feature of this vaccine vector is that its rep

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Generation and Production of Modified Vaccinia Virus Ankara (MVA) as a Vaccine Vectoraccine and responsible for the deaths of one to two people per million vaccinated. Modified Vaccinia virus Ankara (MVA) is an attenuated derivative, also used in the smallpox eradication campaign and now being developed as a recombinant viral vector to produce vaccines against infectious diseases an

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Development of Recombinant Arenavirus-Based Vaccinesolecular and cell biology. The use of cell-based minigenome systems has allowed examining the .- and .-acting factors involved in arenavirus replication and transcription, and the identification of novel anti-arenaviral drug targets without requiring the use of live forms of arenaviruses. Likewise,