Titlebook: Recombinant Antibodies for Cancer Therapy; Methods and Protocol Martin Welschof,Jürgen Krauss Book 2003 Humana Press 2003

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Tailoring Kinetics of Antibodies Using Focused Combinatorial Librariesof binding virtually any molecule including proteins, carbohydrates, nucleic acids, and haptens. The intrinsic features of specificity and affinity when combined offer a great advantage in the discovery of a wide-range of lead drug candidates.

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Humanization of Monoclonal Antibodies by CDR GraftingThe discovery of the process for making rodent monoclonal antibodies (MAbs) 26 years ago by Kohler and Milstein has led to a revolution in the treatment of over 50 major diseases, and has borne an industry whose products today represent 6% of total biotechnology sales. The full potential of this industry has still to be reached.

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Recombinant Single-Chain and Disulfide-Stabilized Fv Immunotoxins for Cancer TherapyThe rapid progress in understanding the molecular biology of cancer cells has made a large impact on the design and development of novel therapeutic strategies.

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Recombinant Antibodies for Cancer Therapy978-1-59259-334-7Series ISSN 1064-3745 Series E-ISSN 1940-6029

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Single-Domain VH Antibody Fragments from a Phage Display Libraryng any given molecular entity (antigen). Antigen recognition is conferred to the antibody by a limited number of hypervariable surface loops, differing in sequence and in length, which are connected to a conserved framework structure.

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1064-3745 s step-by-step. Moreover, each protocol supplies a troubleshooting guide containing detailed information on possible problems and hints for pot- tial solutions. Antibody technology is a subject978-1-61737-250-6978-1-59259-334-7Series ISSN 1064-3745 Series E-ISSN 1940-6029