Titlebook: Receptors, Membrane Transport and Signal Transduction; A. E. Evangelopoulos,J. P. Changeux,K. W. A. Wirtz Conference proceedings 1989 Spri

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Protein Kinases, Protein Phosphatases and the Regulation of Glycogen Metabolisms only been realized since the discovery of enzyme regulation by this type of post-trans1ational modification. The first enzyme found to be regulated by a phosphory1ation-dephosphory1ation mechanism was glycogen phosphorylase, an enzyme that had been Known to exist in two intercovertible forms, phos

innate

Phosphorylase Kinase and Protein Kinase C: Functional Similarities (Krebs, 1986). Two of the most intensively studied groups are Ca.-regulated, i.e. the Ca./calmodulin (CaM)-dependent and the Ca.-phospholipid (diacylglycerol)-dependent protein Kinases. Of the enzymes belonging in the category of Ca./ CaM-dependent Kinases, myosin light chain Kinases (MLCK) are dis

戏服

The Use of Specific Antisera to Locate Functional Domains of Guanine Nucleotide Binding Proteinsily of guanine nucleotide binding proteins (G-proteins) (Gilman, 1987). Members of this family include Gs and Gi, which serve to couple receptors to adenylate cyclase in either a stimulatory or inhibitory fashion, both rod and cone specific forms of transducin which couple the photon receptor rhodop

RAG

Calcium Inhibits GTP-Binding Proteins in Squid Photoreceptorsl-. isomeric form. Photoexcited rhodopsin catalyses guanine nucleotide exchange on the GTP-binding protein transducin. The α-subunit binds GTP and dissociates from the ßγ part of the trimer to activate cyclic GMP phosphodiesterase (cGMP-PDE), which hydrolyses cGMP. The subsequent reduction in cGMP c

易于出错

Degradation of the Invasive Adenylate Cyclase Toxin of Bordetella Pertussis by the Eukaryotic Target these is an adenylate cyclase (AC) which has several unique properties. The location of the enzyme in the bacterium is largely extracytoplasmic and a small amount of it is secreted into the culture medium during exponential growth (Hewlett .., 1976). It is activated up to 1000-fold by the Ca. -bind

无政府主义者

Identification and Characterization of Adenylate Cyclases in Various Tissues by Monoclonal Antibodied multi-component enzyme. The complex contains hormone receptor (R), guanine nucleotide binding proteins (G. and G..) and the catalytic unit (C). Recently the catalyst, a calmodulin-insensitive enzyme from myocardium and a calmodulin-sensitive enzyme from brain has been purified to homogeneity by fo

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