Titlebook: Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease; Deric L. Wheeler,Yosef Yarden Book 2015 Springer Science+Busine

昏迷状态

Nuclear Functions of Receptor Tyrosine Kinases,the nucleus. Several studies have shown that nuclear RTKs are involved in transcriptional regulation, DNA damage response, DNA replication, and drug resistance. In addition, a membrane-associated trafficking mechanism has been reported, which provides a comprehensive pathway for nuclear translocatio

voluble

Kaleidoscope

Endocytosis and Endosomal Sorting of Receptor Tyrosine Kinases,or (EGFR) as the prototypic experimental system, common itineraries and mechanisms of endocytic trafficking of RTKs will be highlighted. The deviations from these common trafficking rules observed in studies of other members of the RTK family will also be discussed.

DEAWL

Structural Features of the Kinase Domain,tracellular ligand-binding domains, which share low or no homology between different receptor families. Another level of diversity is encoded by the flexible intracellular C-terminal tails, which contain different sets of tyrosine phosphorylation sites that couple receptors to unique effector repert

突袭

Targeting Receptor Tyrosine Kinases in Cancer,technological advances enable the individualized therapeutic administration of RTK-targeting agents including monoclonal antibodies, immunotoxins, decoy receptors, tyrosine kinase inhibitors, and other agents. In patients carefully selected by the type of molecular aberration of their tumors, these

incision

Mouse Models of Receptor Tyrosine Kinases,ssess the number of novel mouse models that have been developed during the process of writing this book..Here we have tried to give a comprehensive overview about the mouse models of receptor tyrosine kinases. Although these molecules cannot be fully investigated without considering them in the cont

想象

s is written by experts and underscores commonalities between and among the RTKs. It is an ideal companion volume to .The Receptor Tyrosine Kinase: Families and Subfamilies., which proceeds, family by family through all of the specific subfamilies of RTKs, along with their unique landmarks..978-1-4939-4119-3978-1-4939-2053-2

侵蚀

Erythropoietin

Martin Holcmann,Nicole Amberg,Barbara Drobits,Elisabeth Glitzner,Karin Komposch,Jonathan Robson,Fabi

通知

Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease