| 书目名称 | Recent Progress in the Genetic Epidemiology of Cancer | | 编辑 | Henry T. Lynch (Professor of Medicine, Professor a | | 视频video | | | 图书封面 |  | | 描述 | The discipline of genetic epidemiology pertains to the vertical transmission of the susceptibility (predisposition) to a complex disease in a structured population. This statement meets halfway 1 the broad definitiongiven by N. E. Morton and S. c. Chung in 1978 2 and the concise one given by M. -C. King et al. in 1984. 1t pinpoints the fundamental genetic hypothesis, namely, the existence of an inherited condition that predisposes an individual to a specific disease, and the corresponding subject ofinvestigation, the family. Thus, the genetic epidemiological situation consists of three basic elements: (l) the genealogical structure, (2) the mode of inherit ance (i. e. , the "genetic model") for the trait of interest, and (3) the observable phenotypes of susceptibility. It is clear that genetic epidemiology is a research field posi tioned at the intersection of molecular genetics, population gen etics, and clinical genetics. Perhaps the genealogical tree should be its central element: it evidences something forgotten in mole cular genetics, namely the relationships, and associations with probabilistic and statistical concepts from population genetics. It offers a structure and a | | 出版日期 | Conference proceedings 1991 | | 关键词 | Biostatistik; Cancer genetics; Chromosom; Genetik; Medizinische Informatik; Onkologische Epidemiologie; Re | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-75993-2 | | isbn_softcover | 978-3-540-53022-0 | | isbn_ebook | 978-3-642-75993-2 | | copyright | Springer-Verlag Berlin Heidelberg 1991 |
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