Titlebook: Recent Advances in the Pathophysiology of COPD; Trevor T. Hansel,Peter J. Barnes Book 2004 Birkhäuser Verlag 2004 COPD.CT imaging.exhaled

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1422-7746 t information on the pathophysiology of COPD including an outlook on new therapies. It is of interest to researchers and clinicians in academia as well as in the pharmaceutical industry.978-3-0348-9628-3978-3-0348-7939-2Series ISSN 1422-7746 Series E-ISSN 2296-4525

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Genetics of COPD, far the most important risk factor, only 10–20% of smokers develop symptomatic COPD, and less than 15% of the variation in lung function among smokers can be explained by the extent and duration of cigarette smoking. These data indicate that host and/or environmental factors other than simple expos

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Oxidative Stress in COPD, including damage to lipids, proteins and DNA. There is increasing evidence that oxidative stress is an important feature in inflammatory airway diseases, including chronic obstructive pulmonary disease (COPD) [.–.]. This area of research has received new impetus by the recent development of several

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Proteinases in COPD,degradation of antigens or subtle post-translational processing of proteins. In addition, proteolytic enzymes can play a key role in the initiation or resolution of cascade processes such as coagulation and the complement cascade.

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Mucus hypersecretion in COPD,mplicit in the term chronic bronchitis, is one of three pathophysiological entities comprising COPD, the other two being chronic bronchiolitis (small airways disease) and emphysema (alveolar destruction). The relative contribution of each component to pathophysiology varies between patients, with th

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