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Titlebook: Recent Advances in Nitric Oxide Research; Akira Kitabatake,Ichiro Sakuma Conference proceedings 1999 Springer Japan 1999 cancer.circulatio

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Nitric Oxide Production and Long-term Potentiation in the Rat Hippocampus Following Transient Cerebrs been widely studied as a form of synaptic plasticity that represents a cellular mechanism of learning and memory. Numerous processes and molecules are reported to be involved in LTP mechanisms, and some elements including neurotrophic and transcription factors are likely to be common with those in
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Measurement of Exhaled Nitric Oxide of Lung Originses of airway diseases such as bronchial asthma. However, since the exact source of exhaled NO has not been fully understood, we first examined the effects of endotracheal intubation and of breath holding on exhaled [NO] in normal humans. Using a specially-designed gas sampling system, we divided ex
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Induction of Tetrahydrobiopterin Synthesis in Cardiac Myocytesmmatory mediators, including cytokines, causes a marked depression in myocyte contractile responsiveness to b-adrenergic agonists and has been implicated as a contributor to the pathogenesis of heart failure. Since tetrahydrobiopterin (BH4) is an essential cofactor for NO formation, we investigated
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Regulation and Function of Nitric Oxide in the Livercombination of cytokines synergistically activate iNOS expression in the liver, and we have cloned the first human iNOS gene from cytokine-stimulated hepatocytes. We have also shown that steriods, TGF-β, the heat shock response, and nitric oxide (NO) itself, all down-regulate iNOS expression. In viv
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Role of peroxynitrite and poly-(ADP-ribose) synthetase in shock, inflammation, and ischemia-reperfusinhibitors or PARS and/or genetically engineered cells or animals lacking PARS enzyme demonstrates the role of the PARS pathway in the cellular injury associated with stroke, myocardial and splanchnic ischemia-reperfusion, shock and multiple organ failure, diabetes and arthritis.
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