Titlebook: Recent Advances in Glucocorticoid Receptor Action; A. C. B. Cato,H. Schäcke,K. Asadullah Conference proceedings 2002 Springer-Verlag Berli

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HEED

,Induction and Repression of NF-κB-Driven Inflammatory Genes,cals, other known classes of transcription factors are largely regulated indirectly, i.e., by drugs, which impact upon signal transduction cascades and alter transcription factor modification (phosphorylation, acetylation, nitrosylation, hydroxylation) and/or their nuclear import (Emery et al. 2001; Pandolfi 2001).

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Functional Implications of Glucocorticoid Receptor Trafficking,luding heat shock protein 90 (hsp90). Upon hormone binding, the hormone-receptor complex becomes activated, forms a homodimer, and moves into the nucleus. For transactivation, the hormone-receptor complex binds to glucocorticoid response elements (GRE) in the promoter region of target genes.

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The Dynamics of Intranuclear Movement and Chromatin Remodeling by the Glucocorticoid Receptor,pidly to glucocorticoid response elements (GREs), and remains bound to these elements in the continued presence of ligand. In this configuration, the chromatin-bound receptor is argued to serve a nucleating role, attracting a series of factors necessary for transcriptional activation through protein-protein interactions.

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Immune Monitoring of Glucocorticoid Therapy, side effects are mainly induced via the transactivating mechanisms. Recent results (this volume) suggest that it might be possible to separate the transactivating and transrepressing effects of GC in order to promote anti-inflammatory properties in absence of most of the side effects.

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,The Glucocorticoid Receptor β-Isoform: A Perspective on Its Relevance in Human Health and Disease,rs. In turn, the steroid receptors belong to the nuclear receptor superfamily, which includes the thyroid, retinoid, and vitamin-D receptors. Upon activation by their ligand, these receptors can act as transcription factors, i.e., they can activate or repress the transcription of specific target genes.

GENUS

K. H. Väänänen,P. L. HärkönenSoftware Development Life Cycle (SDLC): Planning, Analysis, .Understand essential computer science concepts and skills. This book focuses on the foundational and fundamental concepts upon which expertise in specific areas can be developed, including computer architecture, programming language, algor

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