Titlebook: Recent Advances in Glucocorticoid Receptor Action; A. C. B. Cato,H. Schäcke,K. Asadullah Conference proceedings 2002 Springer-Verlag Berli

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Glucocorticoid Receptor Antagonism of AP-1 Activity by Inhibition of MAPK Family,through the binding to specific glucocorticoid receptors (GR) which belong to the nuclear receptor superfamily of ligand-modulated transcription factors (Beato et al. 1995; Mangelsdorf et al. 1995). Glucocorticoids regulate their target genes mainly at the transcriptional level, though examples of p

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,The Glucocorticoid Receptor β-Isoform: A Perspective on Its Relevance in Human Health and Disease,ing from altering an organism’s metabolism and behavior to the function of its immune system. Clinically, they are used to treat a wide variety of diseases, including allergic and autoimmune diseases like asthma and rheumatoid arthritis. They are generally effective therapies against these pathologi

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Cooperation of Nuclear Transcription Factors Regulated by Steroid and Peptide Hormones,r processes are under the control of steroid and peptide hormones (Topper and Freeman 1980). Growth and limited differentiation occurs during puberty and requires the action of oestrogen, prolactin and members of the transforming growth factor (TGF)-β family. The epithelial cells form ducts and term

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DNA-Dependent Cofactor Selectivity of the Glucocorticoid Receptor,es. Due to their multiple inhibitory effects on the immune system, glucocorticoids are especially suited for treatment of inflammations and autoimmune diseases, but prolonged therapy results in severe metabolic side effects due to alterations in glucose and lipid metabolism. Further side effects inc

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The Anti-inflammatory Action of Glucocorticoid Hormones,of brakes that limit the response, is decisive for survival of the organism. Imagine a bacterial infection: the uncontrolled response, in form of cytokine release by macrophages, e.g. tumour necrosis factor (TNF)-α, would lead to septic shock and death. Excessive TNF-α levels must therefore be avoid

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Analysis of Glucocorticoid Receptor Function in the Mouse by Gene Targeting, pathological processes (Miller and Blake Tyrrel 1995). The glucocorticoid receptor (GR) mediates the effects of glucocorticoids by positively or negatively influencing gene activity. Glucocorticoid-controlled functions range from the regulation of metabolism, the stress response and control of inna

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Glucocorticoid-Inducible Genes That Regulate T-Cell Function,ons entail cell-to-cell contact, coordination between multiple cells and cell types is carried out through antigen-nonspecific soluble mediators, broadly classified as cytokines and hormones. Messages delivered by the cytokines are for the most part pro-inflammatory and/or immune activating, whereas