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Titlebook: Radiobiology in Radiotherapy; Norman M. Bleehen (Cancer Research Campaign Profes Conference proceedings 1988 Springer-Verlag Berlin Heidel

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Measurement of Human Normal Tissue and Tumour Responses,valuation of new treatment strategies. Retrospective studies of complications in critical normal tissues taught important lessons in the past concerning the potential dangers of hypofractionation (Singh 1978). However, it is unethical to use serious complications as planned end-points in prospective
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Principles of Fractionation in Radiotherapy,might increase the probability of tumour control, decrease effects on normal tissues, or combine optimally with other modalities. In addition, fractionation is the backbone of all research in radiation therapy, since some time-dose regimen must be chosen any time another modality is superimposed”.(C
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Fractionation in the Clinic,adly similar, and no consistent differences in tumour control or normal tissue damage have been demonstrated. Schedules with fewer fractions have been investigated because of the convenience they offer the patient. However, there is evidence that the therapeutic ratio is reduced if 10 or fewer fract
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Radiation Resistance and the Dose-Rate Effect: Experimental,ess or failure in clinical radiotherapy to differences in the inherent radiosensitivity of tumour cells. For some decades, therefore, radiobiological research has concentrated mainly on hypoxia: it was tacitly believed that failure in treatment is usually related to the presence of hypoxic cells, wh
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Clinical Aspects of Particle Therapy,ality itself uncontrolled local disease is often the cause of considerable distress to the patient and thus results in poor quality of life. There is therefore still a great need to improve tumour control at the primary site.
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