Titlebook: RUNX Proteins in Development and Cancer; Yoram Groner,Yoshiaki Ito,Andre van Wijnen Book 2017 This is a U.S. Government work and not under

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The Role of Runx1 in Embryonic Blood Cell Formationogenic endothelium (HE). During midgestation HE cells in multiple intra- and extraembryonic vascular beds leave the vessel wall as they transition into HSPCs in a process termed the endothelial to hematopoietic transition (EHT). Runx1 expression in HE cells orchestrates the transcriptional switch ne

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Runx1 Structure and Function in Blood Cell Developmenty of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that require

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Roles of Runx2 in Skeletal Developmentcrucial transcription factor for osteoblast differentiation, as well as that of bone matrix genes including ., ., and .. Runx2 is also required for chondrocyte maturation, and Runx3 has a redundant function with Runx2 in chondrocyte maturation. Runx2 regulates the expression of ., ., ., and . in cho

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Mitotic Gene Bookmarking: An Epigenetic Mechanism for Coordination of Lineage Commitment, Cell Identtion. Mitotic gene bookmarking, retention of sequence-specific transcription factors at target gene loci, including the RUNX regulatory proteins, provide a novel dimension to epigenetic regulation that sustains cellular identity in progeny cells following cell division. Runx transcription factor ret

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Runx Family Genes in Tissue Stem Cell Dynamicstwo organs, blood and skin, is well documented. This review summarizes currently known Runx functions in the stem cells of these tissues. The fundamental core mechanism(s) mediated by Runx proteins has been sought; however, it appears that there does not exist one single common machinery that govern