Titlebook: RNA Sequence, Structure, and Function: Computational and Bioinformatic Methods; Jan Gorodkin,Walter L. Ruzzo Book 2014 Springer Science+Bu

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1064-3745 n advice from the experts.Includes supplementary material: .The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950‘s, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding

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Concepts and Introduction to RNA Bioinformatics,e field has evolved to exploit multiple sequences to take evolutionary information into account, such as compensating (and structure preserving) base changes. These methods have been developed further and applied for computational screens of genomic sequence. Furthermore, a number of additional dire

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The Principles of RNA Structure Architecture, in biotechnology as drug and sensor. Here we describe the composition and fundamental properties of RNA and how the single-stranded RNA chains fold and shape certain motifs that are repeatedly observed in different structures. Small and large molecular mass RNA binders are being touched upon, as is

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Energy-Directed RNA Structure Prediction,is approach that allow to compute suboptimal foldings, or even the partition function over all possible secondary structures. The latter are essential in order to deal with the inaccuracy of minimum free energy (MFE) structure prediction, and can be used, for example, to derive reliability measures

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An Introduction to RNA Databases,ta collection and curation and discuss their impact on both the scope and accuracy of the resulting databases. Finally, we demonstrate these principles through detailed examination of four leading RNA databases: Noncode, miRBase, Rfam, and SILVA.

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