书目名称 | RNA Sequence, Structure, and Function: Computational and Bioinformatic Methods | 编辑 | Jan Gorodkin,Walter L. Ruzzo | 视频video | | 概述 | Presents current up-to-date methodologies.Features tips on trouble shooting and avoiding known pitfalls.Contains key notes and implementation advice from the experts.Includes supplementary material: | 丛书名称 | Methods in Molecular Biology | 图书封面 |  | 描述 | .The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950‘s, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNA‘s ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other ribo-regulators performing critical tasks in essentially all living organisms, has created a burgeoning interest in this primordial component of the biosphere. However, the structural characteristics and evolutionary constraints on RNA molecules are very different from those of proteins, necessitating development of a completely new suite of informatic tools to address these challenges. In .RNA Sequence, .Structure, Function: Computational and Bioinformatic Methods., expert researchers in the field describe a substantial and relevant fraction of these methodologies from both practical and computational/algorithmic perspectives. Focusing on both of these directions addresses both the biologist interested in knowing more about RNA bioinformatics as well as the bioinformaticist interested in | 出版日期 | Book 2014 | 关键词 | De novo search for structured RNAs; Homology search; RNA 3D Structure; RNA 3D modeling; RNA Bioinformati | 版次 | 1 | doi | https://doi.org/10.1007/978-1-62703-709-9 | isbn_softcover | 978-1-4939-6165-8 | isbn_ebook | 978-1-62703-709-9Series ISSN 1064-3745 Series E-ISSN 1940-6029 | issn_series | 1064-3745 | copyright | Springer Science+Business Media New York 2014 |
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