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Titlebook: RNA Metabolism in Trypanosomes; Albrecht Bindereif Book 2012 Springer-Verlag Berlin Heidelberg 2012 Gene Expression.Molecular Biology.RNA.

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书目名称RNA Metabolism in Trypanosomes
编辑Albrecht Bindereif
视频video
概述Presents the latest findings on RNA metabolism.In depth analysis of trypanosome transcription mechanism.Written by experts in the field
丛书名称Nucleic Acids and Molecular Biology
图书封面Titlebook: RNA Metabolism in Trypanosomes;  Albrecht Bindereif Book 2012 Springer-Verlag Berlin Heidelberg 2012 Gene Expression.Molecular Biology.RNA.
描述Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.
出版日期Book 2012
关键词Gene Expression; Molecular Biology; RNA; RNA Metabolism; RNA Polymerase; Trypanosomes
版次1
doihttps://doi.org/10.1007/978-3-642-28687-2
isbn_softcover978-3-642-43325-2
isbn_ebook978-3-642-28687-2Series ISSN 0933-1891 Series E-ISSN 1869-2486
issn_series 0933-1891
copyrightSpringer-Verlag Berlin Heidelberg 2012
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,RNA Editing in African Trypanosomes: A U-ser’s G-U-ide,ting reaction and I summarize the molecular components and accessory factors of the editosome machinery. Special emphasis is put on the recent discovery of the molecular structure of the editing complex, which allows a first correlation of structural features with functional characteristics.
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Translation in Trypanosomatids,the different environmental conditions. Special attention is given to the unusual finding that differential translation is driven by defined elements in the 3′ UTR, and potential mechanisms are discussed, including structural changes of the RNA. The effects of environmental switches on the translati
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ion would require a serious modification of the one-parameter scaling theory of localization in the sense that the scaling function .(.) should have at least one zero. A possible scenario is indicated in Fig. 4.1 as a dashed line. Another scenario would replace the one-parameter scaling function .(.
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