Titlebook: RNA Interference; Patrick J. Paddison,Peter K. Vogt Book 2008 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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Identifying Human MicroRNAs,th biological and computational, have played an important role in this enfolding drama, and have led to the discovery of many hundreds of novel microRNAs. These different discovery and validation approaches are briefly reviewed here, as are the challenges and questions that lie ahead.

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0070-217X ccesses and failures as we attempt to apply this genetic tool to various biological problems for the first time in academia and industry. Through the introduction of RNAi, mammalian systems have finally gained admittance to the pantheon of model genetic systems. .978-3-642-44445-6978-3-540-75157-1Series ISSN 0070-217X Series E-ISSN 2196-9965

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Structure-Function Relationships Among RNA-Dependent RNA Polymerases,ely that the cellular RdRPs will share some of the basic structural and mechanistic principles gleaned from studies of viral RdRPs. Therefore, studies of the viral RdRP establish a framework for the study of cellular RdRPs, an important yet understudied class of nucleic acid polymerases.

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RNA Silencing in Mammalian Oocytes and Early Embryos,ranscriptional silencing, mRNA degradation, and inhibition of translation. This review will discuss possible roles of RNA silencing pathways in mouse oocytes and early embryos as well as the use of RNA silencing for experimental inhibition of gene expression in this model system.

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江湖郎中

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Role of Dicer in Posttranscriptional RNA Silencing,sis of miRNAs and small interfering RNAs (siRNAs), and also plays an important role in an effector step of RNA silencing, the RNA-induced silencing complex (RISC) assembly. In this article we describe different functions of Dicer in posttranscriptional regulation. We review the current knowledge abo