Titlebook: RNA Interference; Patrick J. Paddison,Peter K. Vogt Book 2008 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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MicroRNA Metabolism in Plants,d precursors that form hairpin structures, with the miRNAs residing in one arm of the stems. miRNAs were first isolated and recognized as regulators of protein-coding genes through forward genetic screens in ., but were not recognized as universal regulators of gene expression in animals until three

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RNAi-Mediated Chromatin Silencing in Fission Yeast,atin, is an epigenetically inherited attribute of eukaryotic chromosomes which is required for gene regulation, chromosome segregation and maintenance of genome stability. In ., heterochromatin forms on related repetitive DNA sequences at specific loci. These repetitive sequences, in concert with th

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A Role for RNAi in Heterochromatin Formation in , , characterizing the heterochromatin structure biochemically and via its effects on genes and transgenes, very little is known about how heterochromatin formation is initiated. Recent evidence from the yeast . suggests the involvement of the RNA interference (RNAi) machinery in heterochromatin format

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RNA-Mediated Transcriptional Gene Silencing in Human Cells,on of a particular gene by targeting the mRNA in a post-transcriptional manner. While there are a plethora of reports applying siRNA-mediated post-transcriptional silencing (PTGS) therapeutically there are apparent limitations such as the duration of the effect and a saturation of the RNA-induced si

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RNA Silencing in Mammalian Oocytes and Early Embryos,veral conserved components. The common denominator of these pathways is the presence of specific, short (21–25 nt) RNA molecules generated from different double-stranded RNA substrates by a specific RNase III activity. Short RNA molecules serve as a template for sequence-specific effects including t

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978-3-030-93234-3The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl