Titlebook: RNA Editing; Methods and Protocol Ernesto Picardi,Graziano Pesole Book 2021 Springer Science+Business Media, LLC, part of Springer Nature 2

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Bioinformatics Resources for RNA Editing,pers and variant callers with a wide range of adjustable parameters, are currently available for the detection of RNA editing events. Hereafter, we describe some of the most recent and popular tools and provide guidelines for the detection of RNA editing in massive transcriptome data.

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Book 2021gents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls...Authoritative and cutting-edge, .RNA Editing: Methods and Protocols .aims to ensure successful results in the further study of this vital field... .

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Discovering RNA Editing Events in Fungi,th a special emphasis on their usability for fungal RNA editing detection. We describe computational protocols for the identification of candidate RNA editing sites in fungi by using two software packages REDItools and RES-Scanner with RNA sequencing (RNA-Seq) and genomic DNA sequencing (DNA-Seq) data.

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,Discovering A-to-I RNA Editing Through Chemical Methodology “ICE-seq”,cal Erasing (ICE) method to accurately and biochemically identify inosines in RNA strands utilizing inosine cyanoethylation and reverse transcription-PCR. Furthermore, we applied this technique to next-generation sequencing technology, called ICE-seq, to conduct an unbiased genome-wide screening of A-to-I editing sites in the transcriptome.

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ALU A-to-I RNA Editing: Millions of Sites and Many Open Questions,ents, the few evolutionary conserved editing sites manage to retain their editing levels. Here, we review and discuss the cost of having an unusual amount of dsRNA and editing in the transcriptome, as well as the opportunities it presents, which possibly contributed to accelerating primate evolution.

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Proteome Diversification by RNA Editing,hich are conserved within (but not usually across) lineages and have functional and evolutionary importance. In this chapter we describe the recoding phenomenon across species, consider its potential utility for diversity and adaptation, and discuss its evolution.

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RNA Editing in Interferonopathies,ranging from cancers to neurological abnormalities..In this review, we briefly summarize the knowledge about the RNA editing alterations occurring in patients with mutations in ADAR1 gene and how these alterations might cause the inappropriate IFN activation.

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