Titlebook: RNA Editing; Methods and Protocol Ernesto Picardi,Graziano Pesole Book 2021 Springer Science+Business Media, LLC, part of Springer Nature 2

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ALU A-to-I RNA Editing: Millions of Sites and Many Open Questions,an a million highly similar copies. A direct outcome of this is an enrichment in long structures of stable dsRNA, which are the target of adenosine deaminases acting on RNAs (ADARs), the enzymes catalyzing A-to-I RNA editing. Indeed, A-to-I editing by ADARs is extremely abundant in primates: over a

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RNA Editing in Human and Mouse Tissues,anisms, including mammals. Multiple studies have demonstrated the importance of this process not just in normal development and physiology but also in various human diseases. Importantly, the precise editing level of a site may have downstream consequences on cellular behavior. Hence, the editing le

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High-Throughput Sequencing to Detect DNA-RNA Changes, of posttranscriptional molecular mechanisms as alternative splicing and RNA editing at unprecedented throughput and resolution. The most prevalent type of RNA editing in higher eukaryotes is the deamination of adenosine to inosine (A-to-I) in double-stranded RNAs. Depending on the RNA type or the R

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Detection of A-to-I Hyper-edited RNA Sequences,ason, current methods to detect A-to-I editing sites work to align RNA sequences to their reference DNA sequence in order to reveal A-to-G mismatches. However, areas with heavily edited reads produce dense clusters of A-to-G mismatches that hinder alignment, and complicate correct identification of

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Proteome Diversification by RNA Editing,ng by double-stranded RNA-specific adenosine deaminase (ADAR) enzymes. Editing of a protein-coding region within the RNA molecule may result in non-synonymous substitutions, leading to a modified protein product. These editing sites, also known as “recoding” sites, contribute to the complexity and d

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RNA Editing in Interferonopathies,ling..The elucidation of the genetic causes of this group of diseases revealed an alteration of nucleic acid processing and signaling..ADAR1 is among the genes found mutated in patients with this type of disorders..This enzyme catalyzes the hydrolytic deamination of adenosines in inosines within a d

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The Role of RNA Editing in the Immune Response,te immune response. One common class of molecules utilized by the innate immune system for self vs. nonself discrimination is RNA, which is ironically present in all forms of life. To avoid self-RNA recognition, the innate immune sensors have evolved sophisticated discriminatory mechanisms that invo

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