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Titlebook: Rho Family GTPases; Ed. Manser (Principle Investigator) Book 2005 Springer Science+Business Media B.V. 2005 Regulation.cell biology.conser

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Cdc42 and Rac Control of the Actin Cytoskeleton,which are elicited in response to extracellular stimuli. This reorganization is achieved by the action of kinases, phosphatases and effectors of Rho GTPases on actincontaining filaments. In this review, we shall discuss how the different proteins such as WASP, WAVE, PAK and IQGAP, which are downstre
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Regulation of Cell-Cell Adhesion by Rho Family GTPases, during development, while disorders of cell adhesion contribute to common diseases, including cancer and inflammation. Given their wide-ranging ramifications, it is not surprising that these interactions are subject to strict cellular regulation. In particular, classical cadherins, major mediators
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Rho Proteins and Vesicle Trafficking,e cell, and between the different intracellular compartments. A lot of attention has been paid in the past decades to the role played by distinct classes of small GTPases on the regulation of membrane trafficking, with special emphasis on the Rab and Arf families. More recently, Rho GTPases have bee
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Genetic Analysis of Rho Protein Function in Mice,on, and motility. Among their well established essential roles is that of organizing the actin cytoskeleton, and this aspect of Rho GTPase function has led to the identification of important roles for various Rho family GTPases in a variety of actin-dependent cellular processes, including cell shape
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Rho Proteins and Microtubules, formation of distinct actin arrays (stress fibers, lamellipodia, and filopodia), with MTs, which are present as extensive and dynamic arrays in the absence of Rho GTPase signaling, Rho GTPases principally modify the behavior and dynamics of individual MTs within an existing array. Despite this seem
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1567-2530 usses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted...The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecula
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RhoA/C and the Actin Cytoskeleton,cle contraction, cell morphology, cell motility, neurite retraction, and polarity formation through their specific effectors. The characterization of these effectors has begun to clarify how Rho regulates some phenotypes. This article focuses on the roles of RhoA/C and their effectors.
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Evolution of the Human Rho GTPase Family, family and attempt to trace the emergence of specific isoforms. We also examine two other factors that contribute to the overall diversity of human Rho GTPase proteins: genetic polymorphism and alternative splicing.
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