Titlebook: RAS Family GTPases; Channing Der Book 2006 Springer Science+Business Media B.V. 2006 Activation.Endoplasmatisches Reticulum.biochemistry.c

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Channing DerFocuses on one of the most intensely studied proteins and areas in cell biology.Establishes many of our current paradigms in the signalling circuitry of a cell.Of interest to researchers in a diverse

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Ras Stories: The State of the Art,the pioneering work by Scolnick and colleagues during the 1970’s that first established the identity of cellular Ras genes as oncogenes and their gene products as guanine nucleotide binding proteins. However, it was not until 1982, when mutationally activated forms of human Ras genes were found in h

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Ras-Gefs and Ras Gaps,oliferation, differentiation or death. Normal Ras proteins exist in equilibrium between an active (Ras-GTP) and an inactive (Ras-GDP) state. Once activated, Ras stimulates a multitude of downstream signaling pathways, but different data about Ras location to plasma membrane subdomains and new roles

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Noncanonical Effector Targets Of Oncogenic Ras Proteins,ly improved over the recent years. The proliferative, anti-apoptotic and some of the more cell-type and tumor-idiosyncratic effects of Ras GTPases in various scenarios could be ascribed to one of these effectors. However, individual tumor cells undergo drastic changes in their cell fates and differe

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Effectors of Ras-Mediated Oncogenesis,rprising that mutationally activated Ras proteins have been found in many human cancers. Determining the effector protein signaling pathways through which Ras causes cellular transformation is important for creating targeted therapeutics that will specifically block the oncogenic effects of activate

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RHO Proteins in RAS Signaling and Transformation,m activities that are mediated by multiple effector pathways. Among the critical Ras targets are the Rho GTPases, which have emerged as a family of proteins that plays an essential role in normal and neoplastic cellular growth, particularly in Ras-induced transformation. How Rho family GTPases relay