Titlebook: Quasispecies: From Theory to Experimental Systems; Esteban Domingo,Peter Schuster Book 2016 The Editor(s) (if applicable) and The Author(s

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ating if it were true, a more than extra- dinary discovery, the answer to an eternal question. There is p- sibly a deep psychological motive in this desire to know if we are alone in this huge universe, and the need to believe in something beyond our limited world, in space and time. There is no dou

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Book 2016 treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology. .

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What Is a Quasispecies? Historical Origins and Current Scope, simplifying assumptions concerning the distribution of fitness values. Error thresholds are regularly found on landscapes with large and irregular scatter of fitness. After the introduction to theory, it will be shown how experimental data on the evolution of molecules or viruses may be fit to the theoretical model.

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Mathematical Models of Quasi-Species Theory and Exact Results for the Dynamics,volution equations into Hamilton–Jacobi equation (HJE). We apply the method to the Crow–Kimura (parallel) and Eigen models. We get simple formulas to calculate the dynamics of the maximum of distribution and the variance. We review the existing mathematical tools of quasi-species theory.

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What Is a Quasispecies? Historical Origins and Current Scope,lly in the spirit of Albert Einstein who said: “Things should be made as simple as possible but not simpler.” More elaborate treatments follow in the forthcoming chapters. It is shown that the most important results of the theory, in particular the existence of error thresholds, are not dependent on

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Evolution of RNA-Based Networks,computer simulation. The adaptation of RNA sequences to external selection pressures is well studied and well understood. The de novo innovation or optimization of RNA aptamers and riboswitches in SELEX experiments serves as a case in point. Likewise, fitness landscapes building upon the efficiently