Titlebook: Quasispecies: Concept and Implications for Virology; Esteban Domingo Book 2006 The Editor(s) (if applicable) and The Author(s), under excl

充足

Quasispecies in Time-Dependent Environments,dressed questions such as how the time scale of the changes affect viral adaptation and quasispecies formation, how environmental changes affect the optimal mutation rate, or how virus and host co-evolve. Here, we review these recent developments, and give a nonmathematical introduction to the most

水土

Viruses as Quasispecies: Biological Implications,to changing environments and the fate of the population as a whole. Mutant spectra are continuously and avoidably generated during RNA genome replication, and they are not just a by-product of error-prone replication, devoid of biological relevance. On the contrary, current evidence indicates that m

Debility

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STENT

Evolutionary Dynamics of HIV-1 and the Control of AIDS,sion to a new host. This presents a great challenge to the prevention and management of HIV-1 infection. At the same time, the relentless diversification of HIV-1, developing as it does under the constraints imposed by the human immune system and other selective forces, contains within it informatio

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Fermentation

Molecular Mechanisms of Poliovirus Variation and Evolution, addition, genetic errors may be introduced by nonreplicative mechanisms. Resulting variability is manifested by point mutations and genomic rearrangements (e.g., deletions, insertions and recombination). After description of basic mechanisms underlying this variability, the review focuses on regula

公理

Hepatitis C Virus Population Dynamics During Infection,ynamics in experimental models and infected patients can provide useful information on factors involved in the HCV life cycle and pathogenicity. HCV quasispecies variability also has therapeutic implications, as the continuous generation and selection of fitter or truly resistant variants can allow

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行乞

Arenavirus Diversity and Evolution: Quasispecies In Vivo,terogeneity is advantageous to the population, allowing for adaptation to rapidly changing environments that present varying types and degrees of selective pressure. The significant variation in biological properties observed among lymphocytic choriomeningitis virus (LCMV) strains, the prototypic ar