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Titlebook: Proteogenomics; Methods and Protocol Jens Allmer,Abhishek Kumar Book 2025 The Editor(s) (if applicable) and The Author(s), under exclusive

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书目名称Proteogenomics
副标题Methods and Protocol
编辑Jens Allmer,Abhishek Kumar
视频video
概述Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
丛书名称Methods in Molecular Biology
图书封面Titlebook: Proteogenomics; Methods and Protocol Jens Allmer,Abhishek Kumar Book 2025 The Editor(s) (if applicable) and The Author(s), under exclusive
描述.This volume presents an up-to-date overview of the current state-of-the-art protocols, and aims to put proteogenomics into a broader perspective. The chapters in this book detail methods and techniques ranging from mass spectrometry to proteomics and proteogenomics and their biomedical implications and applications. Written in the highly successful .Methods in Molecular Biology. series format, the chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. A highlight for everyone new to the field are the chapters, which put proteogenomics to use to answer biomedical questions...Authoritative and accessible, .Proteogenomics: Methods and Protocols .aims to ensure successful results in the further study of this vital field..
出版日期Book 2025
关键词Oncoprotegenomics; biomarkers; peptide mapping; databases; NGS
版次1
doihttps://doi.org/10.1007/978-1-0716-4152-1
isbn_softcover978-1-0716-4154-5
isbn_ebook978-1-0716-4152-1Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
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De Novo Sequencing of Peptides from Tandem Mass Spectra and Applications in Proteogenomics,ng mass spectrometry (MS). Samples are prepared, proteins extracted and then analyzed using MS and MS/MS. The resulting spectra need to be processed computationally to assign peptide spectrum match. Database searches employ sequence databases or spectral libraries for matching possible peptides with
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Genome Annotation,ess heavily relies on genome annotation based on homology detections from previously known genomic data. The rapid advancement of genome sequencing technologies has made genome sequencing affordable and effective in terms of the time frame for the generation of genomic data. Hence, genome sequencing
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Comprehensive Peptide Mapping Is Crucial for Proteogenomics and Proteomics, support at the protein level. Such evidence is usually generated using mass spectrometry and subsequent result mapping to various sequence databases. This workflow entails several problems: (1) To speed up the analysis, only a small set of expected proteins is searched; (2) database search tools ge
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A Review of Protein Inference,f interest, the proteins, are digested into peptides before measurement on a mass spectrometer. This approach introduces a loss of information: The actual proteins must be inferred based on the identified peptides. While this might seem trivial, there are certain problems, one of the biggest being t
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Introduction to Integrated Proteogenomic Pipeline for Dealing with Pathogenic Missense SNPs,mics) with main aims of improving genome annotation and facilitating characterization of proteo-isoforms. However, working with proteogenomic approach is a very challenging task as it is generating multi-omics data and integrating these data for interpretation of results for biological or clinical i
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