| 书目名称 | Proteopathic Seeds and Neurodegenerative Diseases | | 编辑 | Mathias Jucker,Yves Christen | | 视频video | | | 概述 | With contributions from nobel laureats Eric Kandel and Stanley Prusiner.Latest research on prion diseases.Presents developing therapies ?.Includes supplementary material: | | 丛书名称 | Research and Perspectives in Alzheimer‘s Disease | | 图书封面 |  | | 描述 | The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer´s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding an | | 出版日期 | Book 2013 | | 关键词 | Parkinson‘s disease; amyloidosis; prions; synucleinopathies | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-35491-5 | | isbn_softcover | 978-3-642-44696-2 | | isbn_ebook | 978-3-642-35491-5Series ISSN 0945-6066 Series E-ISSN 2196-310X | | issn_series | 0945-6066 | | copyright | Springer-Verlag Berlin Heidelberg 2013 |
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发表于 2025-3-21 16:21:05
