| 书目名称 | Protein Complexes that Modify Chromatin |
| 编辑 | J. L. Workman |
| 视频video | |
| 概述 | Includes supplementary material: |
| 丛书名称 | Current Topics in Microbiology and Immunology |
| 图书封面 |  |
| 描述 | An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The exten sive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cis-acting sequences and trans acting factors. Our view of eukaryotic chromosomes has evolved dra matically over the last decade. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome. Indeed chromatin is so fluid that even maintaining gene quiescence is an active process and is tightly regulated. Chromatin dynamics is a consequence of protein complexes that modify histones, remove histone modifications, mobi lize nucleosomes or stabilize nucleosomes. Awide variety of such com plexes have now been described. Some are abundant and may play glo bal roles in chromoso |
| 出版日期 | Book 2003 |
| 关键词 | Chromosom; DNA; Elongation; biology; chromatin; chromatin dynamics; chromosome; gene expression; genes; heter |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-55747-7 |
| isbn_softcover | 978-3-642-62909-9 |
| isbn_ebook | 978-3-642-55747-7Series ISSN 0070-217X Series E-ISSN 2196-9965 |
| issn_series | 0070-217X |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
发表于 2025-3-21 19:38:05
