| 书目名称 | Programmed Cells from Basic Neuroscience to Therapy |
| 编辑 | Fred H. Gage,Yves Christen |
| 视频video | |
| 概述 | Presents latest research on neurodegenerative diseases.Presents prospects for novel therapies.Written by leading experts in the field ?.Includes supplementary material: |
| 丛书名称 | Research and Perspectives in Neurosciences |
| 图书封面 |  |
| 描述 | The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. |
| 出版日期 | Book 2013 |
| 关键词 | Alzheimer‘s disease; Huntington‘s disease; Neurodegenerative and neurodevelopmental diseases; Programmi |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-36648-2 |
| isbn_softcover | 978-3-662-51294-4 |
| isbn_ebook | 978-3-642-36648-2Series ISSN 0945-6082 Series E-ISSN 2196-3096 |
| issn_series | 0945-6082 |
| copyright | Springer-Verlag Berlin Heidelberg 2013 |
发表于 2025-3-21 16:39:24
