| 书目名称 | Polymyxin Antibiotics: From Laboratory Bench to Bedside |
| 编辑 | Jian Li,Roger L. Nation,Keith S. Kaye |
| 视频video | |
| 概述 | Provides a comprehensive review on pharmacokinetics, pharmacodynamics and toxicity of polymyxins.Clarifies the confusing definitions of potency of colistin used in different parts of the world.Reviews |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | .This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field..It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotox |
| 出版日期 | Book 2019 |
| 关键词 | Antibiotic resistance; Pharmacokinetics; Pharmacodynamics; Clinical use; Polymyxins to infectious diseas |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-030-16373-0 |
| isbn_ebook | 978-3-030-16373-0Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | Springer Nature Switzerland AG 2019 |
发表于 2025-3-21 16:54:03
