| 书目名称 | Phenotypic Variation in Populations | | 副标题 | Relevance to Risk As | | 编辑 | Avril D. Woodhead,Michael A. Bender,Robin C. Leona | | 视频video | | | 丛书名称 | Basic Life Sciences | | 图书封面 |  | | 描述 | The human race has enormous he terogenei ty, founded on genetic and environmental sources. Variability, therefore, is a vital dimension in any consideration of human risk assessment. In the estimation of risks, current methods of extrapolation based upon converting the response of a median man are inadequate, as they ignore phenotypic variation and there fore, susceptible subgroups. There is a growing literature defining the extent of human variation in normal populations; thus, the normal young adult population may have 10-20% known hyperreactors. How far can we ignore human variability in risk assessment? Should we be concerned with susceptible groups, and how can we modify the risk assessment analysis accordingly? The aim of our meeting was to bring together experts from the fields of human epidemiology, toxicology, aging, genetics, carcino genesis and teratology, and to provide a forum in which we might assimi late knowledge of human heterogeneity as a coherent whole. Since the resolution and obligations of risk assessment, in the last analysis, are a political process, we also involved representatives from the legal field, the unions, and the regulatory agencies. We are mos | | 出版日期 | Book 1988 | | 关键词 | aging; assessment; energy; epidemiology; genetics; mutagen; population; research; toxicology | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4684-5460-4 | | isbn_softcover | 978-1-4684-5462-8 | | isbn_ebook | 978-1-4684-5460-4 | | copyright | Springer Science+Business Media New York 1988 |
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发表于 2025-3-21 18:32:04
