| 书目名称 | Pharmacokinetic Challenges in Drug Discovery |
| 编辑 | O. Pelkonen,A. Baumann,A. Reichel |
| 视频video | |
| 丛书名称 | Ernst Schering Foundation Symposium Proceedings |
| 图书封面 |  |
| 描述 | Despite increased spending on research and development, the number of new medicines marketed successfully continues to decline. The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process. One of the biggest challenges is the pharmacokinetic (PK) optimisation of drug candidates tailored and predicted to have appropriate absorption, distribution, metabolism and excretion (ADME) characteristics in human. This book describes how traditional pbarmacokinetic approaches and methods are being re-invented‘ to meet specific needs dictated by the dynamics of the drug discovery process. The book gives an overview of state-of-the-art tools and their use in the decision-making process is discussed by a number of scientists from leading pharmaceutical companies. |
| 出版日期 | Conference proceedings 2002 |
| 关键词 | Drug Metabolism; Pharmocokinetics; absorption; cytochrome P450; drug; drug development; drug discovery; dru |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-662-04383-7 |
| isbn_softcover | 978-3-662-04385-1 |
| isbn_ebook | 978-3-662-04383-7Series ISSN 0947-6075 |
| issn_series | 0947-6075 |
| copyright | Springer-Verlag Berlin Heidelberg 2002 |
发表于 2025-3-21 18:50:19
