| 书目名称 | Peptide and Protein Interaction with Membrane Systems |
| 副标题 | Applications to Anti |
| 编辑 | Sara Bobone |
| 视频video | |
| 概述 | Nominated as an outstanding Ph.D. thesis by the University of Rome Tor Vergata, Italy.Selected as the as the best Italian Ph.D. Physical Chemistry Thesis 2012-2013 by the Italian Chemical Society.Prov |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. Findings which solve several conundrums debated in the literature for years. In addition, Bobone uses liposomes as nanotemplates for the photopolymerization of hydrogels - exploiting the self- assembly properties of phospholipids. Bobone was able to trap an enzyme using nanometeric particles, while still allowing its activity by the diffusion of substrates and products through the network of the polymer. The innovative nano devices described in this thesis could solve many of the hurdles still hampering the therapeutic application of protein-based drugs. |
| 出版日期 | Book 2014 |
| 关键词 | Enzyme Encapsulation; Fluorescence Spectroscopy; Mechanism of Action of Antimicrobial Peptides; Peptide |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-06434-5 |
| isbn_softcover | 978-3-319-38273-9 |
| isbn_ebook | 978-3-319-06434-5Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer International Publishing Switzerland 2014 |
发表于 2025-3-21 17:54:41
