Titlebook: Paraproteinemia and Related Disorders; Gaafar Ragab,Luca Quartuccio,Hadi Goubran Book 2022 The Editor(s) (if applicable) and The Author(s)

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Monoclonal Immunoglobulin Deposition Diseaseoclonal immunoglobulins (mIg). Three subtypes of MIDD have been reported: light chain deposition disease, which is the most common, light- and heavy-chain deposition disease, and heavy-chain deposition disease. An appropriate diagnostic workup may be challenging, owing to the plethora of available l

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Monoclonal Gammopathy of Undetermined Significance (MGUS) and Highlight on Monoclonal Gammopathy of Neurological Significance (MGNS)protein of less than 30 g/L noted on serum protein electrophoresis [SPEP], less than 10% plasma cells in the bone marrow and the absence of end-organ damage (defined by the acronym CRAB for hypercalcemia, renal insufficiency, anemia, or bone lesions) and lack of B-cell lymphoma or other diseases kno

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IgG4-Related Disease Overview: Pathology, Clinical Picture, and Treatmentaracterized by tumor-like fibrotic masses infiltrated by IgG4-expressing B cells and activated fibroblasts. Although IgG4 antibodies have inspired the nomenclature of IgG4-RD, their role in pathogenesis, clinical manifestations, and tissue damage remains debated. Involvement of the pancreato-biliary