Titlebook: Paraproteinemia and Related Disorders; Gaafar Ragab,Luca Quartuccio,Hadi Goubran Book 2022 The Editor(s) (if applicable) and The Author(s)

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B Cell in Health and Diseasehogens through the production of highly diverse and specific antibodies. B-cell development starts in the bone marrow, allowing the formation of a mature B cell equipped with a functional B-cell receptor able to recognize and bind different antigens. The second part of B-cell development proceeds af

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Immunoglobulins, Structure, and Functionroduced by B cells and plasma cells, they can not only provide precise and selective defense against a variety of pathogenic organisms but also lend exquisite specificity to the host defense functions of relatively nonspecific cells of the innate arm of immunity including neutrophils, basophils, eos

Hyperplasia

AUGUR

Animal Models in Monoclonal Immunoglobulin-Related Diseaseseffective strategies for the management of these diseases. This chapter discusses the large variety of animal models which are available for studying both the paraproteinemia disorders themselves and the associated pathologies that arise from the deposition of single immunoglobulin chains or whole i

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Amyloidosis: Pathogenesis, Types, and Diagnosisisfolding of the protein precursors and progressive aggregation into a highly ordered fibrillar structure that causes organ damage..As per International Society of Amyloidosis, at least 36 proteins have been identified that form amyloid deposits in humans..Amyloid deposits may be systemic, affecting

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Amyloidosis: Clinical Manifestations and Treatment(systemic amyloidosis) or, less commonly, deposits in a single organ (organ-specific amyloidosis). In its systemic form, renal, cardiovascular, hematologic, gastrointestinal or neurological, and cutaneous involvements are common. The diagnosis rests essentially on tissue pathology and necessitates t

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Primary Light Chain (AL) Amyloidosis is an increasingly recognized disease. AL amyloidosis remains the commonest amyloid type, but wild-type transthyretin amyloidosis is likely to overtake AL as the commonest amyloid type. Delays in diagnosis remain, and most patients still present with advanced disease. Recognizing disease manifestat