| 书目名称 | PARP Inhibitors for Cancer Therapy |
| 编辑 | Nicola J. Curtin,Ricky A. Sharma |
| 视频video | |
| 概述 | Includes the most up-to-date research on PARP inhibitors and their effects on cancer therapy.Gives a comprehensive review of the history of PARP, including the discovery of the PARP family.Includes a |
| 丛书名称 | Cancer Drug Discovery and Development |
| 图书封面 |  |
| 描述 | .PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors..PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.. |
| 出版日期 | Book 2015 |
| 关键词 | DNA repair; PARP; cancer; carcinogenesis; drug resistance; inhibitors; antibacterial drug resistance |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-14151-0 |
| isbn_softcover | 978-3-319-34489-8 |
| isbn_ebook | 978-3-319-14151-0Series ISSN 2196-9906 Series E-ISSN 2196-9914 |
| issn_series | 2196-9906 |
| copyright | Springer International Publishing Switzerland 2015 |
发表于 2025-3-21 19:11:01
