Titlebook: Oxidative Stress and Neuroprotection; H. Parvez,P. Riederer Book 2006 Springer-Verlag Vienna 2006 Alzheimer.Morbus Parkinson.Parkinson.alz

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The relationship of early studies of monoamine oxidase to present concepts,bitors (MAOIs) have evolved, slowly at times and rapidly at other times, with leaps propelled by new discoveries, new techniques and new insights. Moussa Youdim was one of the major contributors to propulsion of several of these leaps, including the detection of multiple forms of MAO, the descriptio

Decibel

,Isatin, an endogenous MAO inhibitor, and a rat model of Parkinson’s disease induced by the Japaneseations in the rat brain and also significantly increased acetylcholine and dopamine (DA) levels in the rat striatum. Urinary isatin concentrations in patients with Parkinson’s disease tend to increase according to the severity of disease. We have developed a rat model of Parkinson’s disease induced

amyloid

奴才

Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine,f bovine semicarbazide-sensitive amine oxidase (EC 1.4.3.6; SSAO) were studied. Hydroxyzine was found to be a competitive inhibitor of MAO-B (K. ∼ 38 µM), whereas it had a low potency towards MAO-A (IC. > 630 µM). Although it was a relatively potent competitive inhibitor of bovine plasma SSAO (K. ∼

Evocative

,Neuroprotection for Parkinson’s disease,tion. For example, defects in mitochondrial metabolism and evidence for oxidative stress in PD have fostered therapeutic interventions aimed at slowing disease progression. More than a dozen compounds already have been tested in PD for disease modification, and others are in planning stages for clin

Ingenuity

,Marker for a preclinical diagnosis of Parkinson’s disease as a basis for neuroprotection,dopaminergic neurons of the substantia nigra have already degenerated, when the diagnosis may be established. At this “advanced stage” neuroprotective strategies will — if at all — only have limited effect. It is, therefore, essential to establish markers to identify subjects at risk before motor ma

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Novel neuroprotective neurotrophic NAP analogs targeting metal toxicity and oxidative stress: poten Metal (Fe, Cu, Zn) dyshomeostasis and oxidative stress are believed to play a pivotal role in the pathogenesis of these diseases. Accordingly, multifunctional compounds combining metal chelating and antioxidative activity hold a great promise as potential drugs for treating AD and PD. In this study