Titlebook: Oxidative Stress and Aging; R. G. Cutler,L. Packer,A. Mori Conference proceedings 1995 Birkhäuser Verlag, Basel, Switzerland 1995 Biochemi

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Formation of 8-hydroxyguanine in DNA by aging and oxidative stressthe levels of oxidative DNA damage, 8-hydroxyguanine (oh.Gua, 7,8-dihydro-8-oxoguanine) and(or) its repair activity in various tissues or cultured cells were quantitated. The following results were obtained from these experiments. (1) The highest level of oh.Gua and its repair activity were found in

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Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stressA-reactive intermediates of nutrient and oxygen metabolism. Profiles and levels of I-compounds depend on species, strain, tissue, and gender, but are also affected by diet and chemical exposures, indicating that their formation is determined by genetic and environmental factors. A gradual depletion

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Iron-induced carcinogenesis in experimental animals: A free radical mechanism of DNA damage and carce used as a redox intermediate in many biological mechanisms. However, it is precisely because of this redox potential that iron is a key participant of free radical production. In this symposium, we briefly review the current research on the relationship between iron and cancer, and discuss our res

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Novel approaches toward inhibition of the Maillard reaction ,: Search, isolation and characterizatiothe damage results from the formation of Amadori products which act as precursors of protein crosslinks and a potent source of free radicals. Seeking to reverse the glycation reaction we have grown soil organisms onto glycated substrate as sole carbon source. From a . sp. we have isolated a novel pr

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Age-associated changes of oxidative modification and turnover of proteinsepancies, however, appear to exist in age-associated changes in carbonyl content as a marker of oxidation of tissue proteins. Antibodies against oxidized proteins treated with dinitrophenyl hydrazine were prepared. The antibodies detected age- and tissue-specific patterns of carbonylated proteins by

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Mitochondria, free radicals, neurodegeneration and agingce, 1992). Over the same period evidence has also been presented which suggests that mutations of mitochondrial DNA (mtDNA) and a decline in respiratory chain function contribute to the aging process. This chapter will review the lessons that can be learned from our study of inborn metabolic defects

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