Titlebook: Osteoporosis; Pathophysiology and Benjamin Z. Leder,Marc N. Wein Book 2020Latest edition Springer Nature Switzerland AG 2020 Biomechanics

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Denosumab: Mechanisms and Therapeutic Effects in the Treatment of Osteoporosis,e healing. BMD increases with denosumab are greater than with bisphosphonates. Discontinuation of denosumab is followed by a rapid decrease in BMD, a rise in bone turnover marker levels to above baseline, and a return of vertebral fracture risk to baseline with an apparent increase in the risk of mu

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The Parathyroid Hormone Receptor Type 1,ies to different PTHR1 conformations to thus induce different types of signaling responses, including prolonged cAMP responses from endosomes. These distinct modes of action suggest potential new paths to explore for therapeutic ligand development. A number of diseases are linked to mutations in the

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PTH and PTHrP Analogs: Treatment of Osteoporosis,ith its cognate ligands (e.g., PTH and PTHrP) than the R0 conformation in which the interaction is longer-lived. Theoretically, the affinity of a PTH or PTHrP ligand for the RG conformation, or a preferential ratio of affinity RG > R0, would help to define actions as more anabolic. Abaloparatide app

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